Selected Publications

Fzd5, GPCR, H. sapiens

N Tsutsumi, S Mukherjee, D Waghray, CY Janda, KM Jude, Y Miao, JS Burg, NG Aduri, AA Kossiakoff, C Gati*, KC Garcia*
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.

eLife. 2020.

GABA(B), GPCR, H. sapiens

H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C Gati*, V Cherezov*
Structural basis of the activation of a metabotropic GABA receptor.

Nature. 2020.

Rv1819c, ABC Transporter, M. tuberculosis

S Rempel, C Gati*, M Nijland, C Thangaratnarajah, A Karyolaimos, JW de Gier, A Guskov*, DJ Slotboom*.
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Nature. 2020.

beta2-adrenergic receptor, B2AR, GPCR, H. sapiens

A Ishchenko, B Stauch, GW Han, A Batyuk, A Shiriaeva, C Li, N Zatsepin, U Weierstall, W Liu, E Nango, T Nakane, R Tanaka, K Tono, Y Joti, S Iwata, I Moraes, C Gati, V Cherezov.
Toward G protein-coupled receptor structure-based drug design using X-ray lasers.

IUCrJ. 2019.

Melatonin receptor 1A, MT1, GPCR, H. sapiens

B Stauch, LC Johansson, JD McCorvy, N Patel, GW Han, XP Huang, C Gati, A Batyuk, ST Slocum, A Ishchenko, W Brehm, TA White, N Michaelian, C Madsen, L Zhu, TD Grant, JM Grandner, A Shiriaeva, RHJ Olsen, AR Tribo, S Yous, RC Stevens, U Weierstall, V Katritch, BL Roth, W Liu, V Cherezov.
Structural basis of ligand recognition at the human MT 1 melatonin receptor.

Nature. 2019.

Melatonin receptor 1B, MT2, GPCR, H. sapiens

LC Johansson, B Stauch, JD McCorvy, GW Han, N Patel, XP Huang, A Batyuk, C Gati, ST Slocum, C Li, JM Grandner, S Hao, RHJ Olsen, AR Tribo, S Zaare, L Zhu, NA Zatsepin, U Weierstall, S Yous, RC Stevens, W Liu, BL Roth, V Katritch, V Cherezov.
XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity.

Nature. 2019.

A Ishchenko, C Gati, V Cherezov.
Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM.

Current Opinion in Structural Biology. 2018.

Neutral amino acid transporter B(0), ASCT2, SLC, H. sapiens

AA Garaeva, GT Oostergetel, C Gati, A Guskov, C Paulino, DJ Slotboom.
Cryo-EM structure of the human neutral amino acid transporter ASCT2.

Nature Structural and Molecular Biology. 2018.